evidencia

BIBLIOGRAFÍA

Effect of vitamin C on blood glucose, serum lipids & serum insulin in type 2 diabetes patients.
Afkhami-Ardekani M, Shojaoddiny-Ardekani A.
Indian J Med Res. 2007 Nov;126(5):471-4.

Diabetes mellitus is controlled by vitamin C treatment.
Kodama M, Kodama T, Murakami M, Kodama M.
In Vivo. 1993 Nov-Dec;7(6A):535-42.

Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?
Lee DH, Folsom AR, Harnack L, Halliwell B, Jacobs DR Jr.
Am J Clin Nutr. 2004 Nov;80(5):1194-200.

Ascorbic acid and blood coagulation.
DAYTON PG, WEINER M.
Ann N Y Acad Sci. 1961 Apr 21;92:302-6.

Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis.
Tyml K.
Microcirculation. 2011 Feb;18(2):152-62.

Impaired capacity for acute endogenous fibrinolysis in smokers is restored by ascorbic acid.
Kaehler J, Koeke K, Karstens M, Schneppenheim R, Meinertz T, Heitzer T.
Free Radic Biol Med. 2008 Feb 1;44(3):315-21.

Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes.
Hoffman RP, Dye AS, Bauer JA.
Pediatr Diabetes. 2012 Dec;13(8):607-10.

Does short-term vitamin C reduce cardiovascular risk in type 2 diabetes?
Gutierrez AD, Duran-Valdez E, Robinson I, de Serna DG, Schade DS.
Endocr Pract. 2013 Sep-Oct;19(5):785-91

Ascorbic acid prevents high glucose-induced apoptosis in human brain pericytes.
May JM, Jayagopal A, Qu ZC, Parker WH.
Biochem Biophys Res Commun. 2014 Sep 12;452(1):112-7.

Vitamin C intake reduces the cytotoxicity associated with hyperglycemia in prediabetes and type 2 diabetes.
Franke SI, Müller LL, Santos MC, Fishborn A, Hermes L, Molz P,
Biomed Res Int. 2013;2013:896536.

Plasma vitamin C, but not vitamin E, is associated with reduced risk of heart failure in older men.
Wannamethee SG, Bruckdorfer KR, Shaper AG, Papacosta O, Lennon L, Whincup PH.
Circ Heart Fail. 2013 Jul;6(4):647-54.

The effect of vitamin C on endothelial function of children with type 1 diabetes: an experimental study.
Sabri MR, Tavana EN, Ahmadi A, Hashemipour M.
Int J Prev Med. 2014 Aug;5(8):999-1004.

Gastric ulceration in diabetes mellitus: protective role of vitamin C.
Owu DU, Obembe AO, Nwokocha CR, Edoho IE, Osim EE.
ISRN Gastroenterol. 2012;2012:362805.

SOPORTE INMUNOLÓGICO

J Aquat Anim Health. 2015 Sep;27(3):178-84.
Influence of Dietary Ascorbic Acid on the Immune Responses of Juvenile Korean Rockfish Sebastes schlegelii.
Kim JH, Kang JC.

Antioxid Redox Signal. 2013 Dec.
Vitamin C promotes maturation of T-cells.
Manning J, Mitchell B, Appadurai DA, Shakya A, Pierce LJ, Wang H, Nganga V, Swanson PC, May JM, Tantin D, Spangrude GJ.

Nutrients. 2015 Apr 9;7(4):2574-88.
Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit.
Bozonet SM, Carr AC, Pullar JM, Vissers MC.

Mol Nutr Food Res. 2015 Aug;59(8):1513-23.
Ascorbic acid modulates cell migration in differentiated HL-60 cells and peripheral blood leukocytes.
Schwager J, Bompard A, Weber P, Raederstorff D.

Inflamm Allergy Drug Targets. 2011 Feb;10(1):54-63. Review.
Micronutrients at the interface between inflammation and infection--ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid.
Ströhle A, Wolters M, Hahn A.

Vnitr Lek. 2012 Oct;58(10):743-9. Review.
Vitamin C and its physiological role with respect to the components of the immune system.
Holmannová D, Koláčková M, Krejsek J.

COLÁGENO

Europea Journal ofDermatology 4, 1994, págs. 271-280.
Structure and function of the cutaneous extracellular matrix.
AUMAILLEY, M. y KRIEG, T.

Plenum Press, Nueva York, 1991.
Cell Biology ofthe Extracellular Matrix.
HAY, E. D.

New York Academic of Sciences, Nueva York, 1990.
Structure, Molecular Biology, and Pathology of Collagen.
Fleischmajer, R., O.sen, B. B. y kühn, K.

J. Indian Med. Assoc. 64: 120-3 (1975).
Leucocyte ascorbic acid and wound infection.
Sayed, S.M., P.B. Roy & P.T. Acharya.

Dermatol Arg. 2006; 12: 141-2
Equimosis en pierna izquierda, púrpura y gingivitis.
Brusco J, Martínez Chabbert P, Bacchiocchi M, Velocci M, y cols.

PROTECCIÓN ANTIOXIDANTE

J Postgrad Med. 2007 Jul-Sep;53(3):207-13.
The oxidative hypothesis of senescence.
Gilca M1, Stoian I, Atanasiu V, Virgolici B.

Nature. 2000 Nov 9;408(6809):239-47.
Oxidants, oxidative stress and the biology of ageing.
Finkel T1, Holbrook NJ.

Cardiovasc Drug Rev. 2005 Summer;23(2):115-32.
Oxidative stress and cardiovascular disease: antioxidants and unresolved issues.
Sachidanandam K1, Fagan SC, Ergul A.

Nutr Res Rev. 2008 Jun;21(1):3-12. doi: 10.1017/S0954422408018076.
Does physical exercise modify antioxidant requirements?.
Margaritis I1, Rousseau AS.

Evid Rep Technol Assess (Summ). 2003 Oct;(75):1-3.
Effect of the supplemental use of antioxidants vitamin C, vitamin E, and coenzyme Q10 for the prevention and treatment of cancer.
Shekelle P, Hardy ML, Coulter I.

Nutr Clin Care. 2002 Mar-Apr;5(2):66-74.
Vitamin C function and status in chronic disease.
Jacob RA1, Sotoudeh G.

J Androl. 2008Sep-Oct;29(5):488-98. doi:10.2164/jandrol.108.005132. Epub 2008 Jun 20.
Oxidative stress: a common factor in testicular dysfunction.
Turner TT1, Lysiak JJ.

EJERCICIO Y DEPORTE

Archivos de Medicina del Deporte. Volumen XXIII - N.º 112 – 2006.
Vitamin c supplementation and sport performance.
BARBANY JR.

Keast D, Cameron K,Morton AR.
Exercise and the inmune response.
Sports Med 1988;5:248-67.

Gleeson M, Robertson JD, Maughan RJ.
Influence of exercise on ascorbic acidstatus in man.
Clin Sci 1987;73:501-5.
Peters EM, Anderson R, Nieman DC, Fickl H, Jogessar V.
Vitamin C supplementation attenuates the increses in circulating cortisol, adrenaline and anti-inflamatory polypeptides following ultramarathon running.
Int J Sports Med (2001b);22:537-43.

De la Fuente M, Fernandez MD, Buegos MS, Soler A, Prieto A, Miquel J.
Inmune function in aged women is improved by ingestion of vitamins C and E.
Can J Physiol Pharmacol 1998;76(4):373-80.

Khassaf M, McArdle A, Esanu C, Vasilaki A, McArdle F, Griffiths RD, et al.
Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle.
J Physiol 2003;549:645- 52.

Peters EM, Goetzsche JM, Joseph LE, Noakes TD.
Vitamin C supplementation reduces the incidence of postrace symptons of upper-respiratory-tract infection in ultramarathon runners.
Am J Clin Nutr 1993;57:170-4.

Hemilä H.
Vitamin C and infectious diseases.
En: (Ed.) Packer L, Fuchs J. Vitamin C in Health and Disease. NY: Marcel Dekker, 1997:471-503.

Himmelstein SA, Robergs RA, Koehler KM, Lewis SL, Qualls CR.
Vitamin C supplementation and upper respiratory tract infections in maraton runners.
J Exerc Physiol Online 1998;1(2):1-21.

Peters EM, Goetzsche JM, Joseph LE, Noakes TD.
Vitamin C as effective as combination of antioxidants nutrients in reducing symptoms of upper respiratory tract infection in ultramaraton runners.
South African J Sports Med 1996;11:23-7.

REVITALIZACIÓN

FASEB J. 2010 Jan;24(1):158-72.
Vitamin C restores healthy aging in a mouse model for Werner syndrome.
Massip L, Garand C, Paquet ER.

Cell Mol Life Sci. 2016 Feb 4. [Epub ahead of print].
The epigenetic role of vitamin C in health and disease.
Camarena V, Wang G.

Annu Rev Nutr. 2015;35:545-64.
Regulation of the Epigenome by Vitamin C.
Young JI, Züchner S, Wang G.

DIABETES

Effect of vitamin C on blood glucose, serum lipids & serum insulin in type 2 diabetes patients.
Afkhami-Ardekani M, Shojaoddiny-Ardekani A.
Indian J Med Res. 2007 Nov;126(5):471-4.

Diabetes mellitus is controlled by vitamin C treatment.
Kodama M, Kodama T, Murakami M, Kodama M.
In Vivo. 1993 Nov-Dec;7(6A):535-42.

Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?.
Lee DH, Folsom AR, Harnack L, Halliwell B, Jacobs DR Jr.
Am J Clin Nutr. 2004 Nov;80(5):1194-200.

Ascorbic acid and blood coagulation.
DAYTON PG, WEINER M.
Ann N Y Acad Sci. 1961 Apr 21;92:302-6.

Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis.
Tyml K.
Microcirculation. 2011 Feb;18(2):152-62.

Impaired capacity for acute endogenous fibrinolysis in smokers is restored by ascorbic acid.
Kaehler J, Koeke K, Karstens M, Schneppenheim R, Meinertz T, Heitzer T.
Free Radic Biol Med. 2008 Feb 1;44(3):315-21.

Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes.
Hoffman RP, Dye AS, Bauer JA.
Pediatr Diabetes. 2012 Dec;13(8):607-10.

Does short-term vitamin C reduce cardiovascular risk in type 2 diabetes?.
Gutierrez AD, Duran-Valdez E, Robinson I, de Serna DG, Schade DS.
Endocr Pract. 2013 Sep-Oct;19(5):785-91.

Ascorbic acid prevents high glucose-induced apoptosis in human brain pericytes.
May JM, Jayagopal A, Qu ZC, Parker WH.
Biochem Biophys Res Commun. 2014 Sep 12;452(1):112-7.

Vitamin C intake reduces the cytotoxicity associated with hyperglycemia in prediabetes and type 2 diabetes.
Franke SI, Müller LL, Santos MC, Fishborn A, Hermes L, Molz P.
Biomed Res Int. 2013;2013:896536.

Plasma vitamin C, but not vitamin E, is associated with reduced risk of heart failure in older men.
Wannamethee SG, Bruckdorfer KR, Shaper AG, Papacosta O, Lennon L, Whincup PH.
Circ Heart Fail. 2013 Jul;6(4):647-54.

The effect of vitamin C on endothelial function of children with type 1 diabetes: an experimental study.
Sabri MR, Tavana EN, Ahmadi A, Hashemipour M.
Int J Prev Med. 2014 Aug;5(8):999-1004.

Gastric ulceration in diabetes mellitus: protective role of vitamin C.
Owu DU, Obembe AO, Nwokocha CR, Edoho IE, Osim EE.
ISRN Gastroenterol. 2012;2012:362805.

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